Our goal is to understand how neurons and neuronal circuits generate and maintain normal function.

We use a variety of tools and approaches to study the biology and function of neurons and circuits in vivo, including genomics, sub-cellular imaging, single-neuron laser surgery and optogenetics. Because C. elegans is transparent and has a simple nervous system, we can manipulate and observe individual neurons in intact, living animals.

We are interested in discovering how neurons choose their fate; how neurons and neural circuits respond to injury, disease, and age; and how molecular mechanisms such as RNA processing, mitochondria traffic, and intracellular signaling affect neuronal function. One major focus is axon regeneration. A new project (CeNGEN) seeks to generate and analyze an ultra-high density map of neuronal gene expression.

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June 14             MSS on functional axon regeneration up on bioRxiv

June 14             Happy birthday Chen

June 4               Lewie's thesis defense

May 31              Neurobiology course starts at the MBL

May 29              Kavli Workshop on single-cell genomics in neuroscience--presenting our work on CenGEN

May 24              Seminar at CSU--presenting our work on RNA biology

May 23              Seminar at CU--keynote--presenting our work on functional axon regeneration

May 21              Eitan starts--welcome

May 21              Yale commencement

April 20             MSS on APP and regeneration up on bioRxiv

March 26          Alec starts--welcome

March 20          ADRC annual meeting--presenting our work on APP in C. elegans

March 8            Seminar at Johns Hopkins

January 18        Seminar at NIH