Our goal is to understand how neurons and neuronal circuits generate and maintain normal function.
We use a variety of tools and approaches to study the biology and function of neurons and circuits in vivo, including genomics, sub-cellular imaging, single-neuron laser surgery and optogenetics. Because C. elegans is transparent and has a simple nervous system, we can manipulate and observe individual neurons in intact, living animals.
We are interested in discovering how neurons choose their fate; how neurons and neural circuits respond to injury, disease, and age; and how molecular mechanisms such as RNA processing, mitochondria traffic, and intracellular signaling affect neuronal function. One major focus is axon regeneration. A new project (CeNGEN) seeks to generate and analyze an ultra-high density map of neuronal gene expression.
June 14 MSS on functional axon regeneration up on bioRxiv
June 14 Happy birthday Chen
June 4 Lewie's thesis defense
May 31 Neurobiology course starts at the MBL
May 29 Kavli Workshop on single-cell genomics in neuroscience--presenting our work on CenGEN
May 24 Seminar at CSU--presenting our work on RNA biology
May 23 Seminar at CU--keynote--presenting our work on functional axon regeneration
May 21 Eitan starts--welcome
May 21 Yale commencement
April 20 MSS on APP and regeneration up on bioRxiv
March 26 Alec starts--welcome
March 20 ADRC annual meeting--presenting our work on APP in C. elegans
March 8 Seminar at Johns Hopkins
January 18 Seminar at NIH