Our goal is to understand how neurons and neuronal circuits generate and maintain normal function, to analyze how they regulate their response to injury, disease, and age, and to identify ways to control these processes at the molecular level. We use a variety of tools and approaches to studying individual neurons in vivo, including novel RNAi-based techniques, single-neuron laser surgery and optogenetics. Because C. elegans is transparent and has a simple nervous system, we can manipulate and observe individual neurons in intact, living animals. A major current focus in the lab is understanding the genetics and cell biology of axon regeneration. We have identified several novel regeneration pathways, and are working to link regeneration to functional recovery; to understand how age affects regenerative potential; and to use genetics and genomics to identify additional components of regeneration. A new project (CeNGEN) seeks to generate and analyze an ultra-high density map of neuronal gene expression.

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2018

June 14             MSS on functional axon regeneration up on bioRxiv

June 14             Happy birthday Chen

June 4               Lewie's thesis defense

May 31              Neurobiology course starts at the MBL

May 29              Kavli Workshop on single-cell genomics in neuroscience--presenting our work on CenGEN

May 24              Seminar at CSU--presenting our work on RNA biology

May 23              Seminar at CU--keynote--presenting our work on functional axon regeneration

May 21              Eitan starts--welcome

May 21              Yale commencement

April 20             MSS on APP and regeneration up on bioRxiv

March 26          Alec starts--welcome

March 20          ADRC annual meeting--presenting our work on APP in C. elegans

March 8            Seminar at Johns Hopkins

January 18        Seminar at NIH