Image: Byrne et al. 2014

Image: Byrne et al. 2014

Aging

How individual neurons age, the cellular pathways that regulate this process, and the ultimate effects of aging on neuronal function, are poorly understood.

We are investigating how aging affects axon regeneration and other cellular functions. We discovered that aging in neurons can be decoupled from overall lifespan by manipulating the InsR/FOXO daf-2/daf-16 pathway.